Tetrahydrocannabivarin

Tetrahydrocannabivarin (THCV) is a compound found in the Cannabis plant. It is one of many cannabinoids present in the plant, and has unique properties that distinguish it from other cannabinoids such as THC and CBD.

Chemistry

THCV is a homologue of THC, but with a propyl (3-carbon) side chain instead of a pentyl (5-carbon) group on the molecule, which makes it produce very different effects from THC. It is a pale yellow resin or crystal with a melting point of 220-225 °C and a boiling point of 428 °F (220 °C).

Pharmacology

THCV has been found to be a CB1 receptor antagonist, unlike THC which is a CB1 agonist. This means that it can reduce the effects of THC. However, at higher doses, THCV has been found to act as a CB1 agonist, similar to THC. It is also a CB2 receptor partial agonist, which may give it potential therapeutic roles in the treatment of inflammation and pain.

Medical uses

Research into the medical uses of THCV is still in its early stages. However, preliminary studies suggest that it may have potential in the treatment of obesity-associated glucose intolerance. It has also been suggested that THCV could be used in the treatment of Parkinson's disease, as it has been shown to have neuroprotective effects.

Legal status

The legal status of THCV varies by country and often depends on its source. In many jurisdictions, it is legal if it is derived from hemp, but illegal if it is derived from other strains of cannabis.

See also

• Cannabinoid
• Cannabis (drug)
• Tetrahydrocannabinol
• Cannabidiol