Tetranectin

Tetranectin is a protein that in humans is encoded by the CLEC3B gene. It is a plasma protein found in tissues and extracellular matrix. Tetranectin is believed to be involved in wound healing and tissue remodeling.

Structure

Tetranectin is a small C-type lectin, which is a type of carbohydrate-binding protein. It is composed of three identical subunits, each of which binds to a specific kind of kringle structure. The protein is encoded by the CLEC3B gene, which is located on chromosome 3 in humans.

Function

Tetranectin binds to plasminogen, a protein involved in the breakdown of blood clots. This binding is believed to enhance the conversion of plasminogen to plasmin, which is the active form of the protein. Tetranectin may also play a role in other biological processes, such as cell adhesion and cell migration.

Clinical significance

Alterations in the level of tetranectin in the blood have been associated with various diseases. For example, decreased levels of tetranectin have been observed in patients with cancer, rheumatoid arthritis, and sepsis. However, the exact role of tetranectin in these diseases is not fully understood.

Research

Research is ongoing to further understand the role of tetranectin in health and disease. This includes studies to determine the exact mechanism by which tetranectin influences the conversion of plasminogen to plasmin, as well as research to investigate the potential use of tetranectin as a biomarker for certain diseases.

File:Tetranectin.png

Tetranectin protein structure

See also

• C-type lectin
• Plasminogen
• Kringle