Thiomuscimol
Thiomuscimol is a GABA receptor antagonist. It is a derivative of the naturally occurring neurotransmitter muscimol, but has been chemically modified to change its activity profile. Thiomuscimol is used in scientific research to study the function of the GABA system in the brain.
Chemistry[edit | edit source]
Thiomuscimol is a derivative of muscimol, which is a naturally occurring neurotransmitter found in the Amanita muscaria mushroom. The chemical structure of thiomuscimol is similar to that of muscimol, but it has a sulfur atom in place of the oxygen atom in the five-membered ring of muscimol. This modification changes the activity of the molecule, making it an antagonist of the GABA receptor rather than an agonist.
Pharmacology[edit | edit source]
Thiomuscimol acts as an antagonist at the GABA receptor, meaning it blocks the action of GABA at this receptor. This is in contrast to muscimol, which is an agonist at the GABA receptor and mimics the action of GABA. The GABA system is the main inhibitory neurotransmitter system in the brain, and so blocking this system with thiomuscimol can lead to increased neuronal activity.
Uses in research[edit | edit source]
Thiomuscimol is used in scientific research to study the function of the GABA system in the brain. By blocking the action of GABA at the GABA receptor, researchers can investigate the role of this system in various aspects of brain function, including neurotransmission, neuroplasticity, and the regulation of sleep and wakefulness.
See also[edit | edit source]
| Thiomuscimol Resources | |
|---|---|
|
 |
Search WikiMD
Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro / Zepbound) available.
Advertise on WikiMD
|
WikiMD's Wellness Encyclopedia |
| Let Food Be Thy Medicine Medicine Thy Food - Hippocrates |
Translate this page: - East Asian
中文,
日本,
한국어,
South Asian
हिन्दी,
தமிழ்,
తెలుగు,
Urdu,
ಕನ್ನಡ,
Southeast Asian
Indonesian,
Vietnamese,
Thai,
မြန်မာဘာသာ,
বাংলা
European
español,
Deutsch,
français,
Greek,
português do Brasil,
polski,
română,
русский,
Nederlands,
norsk,
svenska,
suomi,
Italian
Middle Eastern & African
عربى,
Turkish,
Persian,
Hebrew,
Afrikaans,
isiZulu,
Kiswahili,
Other
Bulgarian,
Hungarian,
Czech,
Swedish,
മലയാളം,
मराठी,
ਪੰਜਾਬੀ,
ગુજરાતી,
Portuguese,
Ukrainian
Medical Disclaimer: WikiMD is not a substitute for professional medical advice. The information on WikiMD is provided as an information resource only, may be incorrect, outdated or misleading, and is not to be used or relied on for any diagnostic or treatment purposes. Please consult your health care provider before making any healthcare decisions or for guidance about a specific medical condition. WikiMD expressly disclaims responsibility, and shall have no liability, for any damages, loss, injury, or liability whatsoever suffered as a result of your reliance on the information contained in this site. By visiting this site you agree to the foregoing terms and conditions, which may from time to time be changed or supplemented by WikiMD. If you do not agree to the foregoing terms and conditions, you should not enter or use this site. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates Wikipedia, licensed under CC BY SA or similar.
Contributors: Prab R. Tumpati, MD
