Thiamylal

Thiamylal is a barbiturate derivative that was first synthesized in the 1950s. It is primarily used as an anesthetic in veterinary medicine, particularly for the induction of anesthesia in dogs and cats, and for the maintenance of anesthesia in horses.

Etymology

The name "thiamylal" is derived from the chemical structure of the compound, which includes a thiophene ring and an amyl group. The "-al" suffix is common in the names of barbiturates, indicating the presence of a carbonyl group.

Pharmacology

Thiamylal is a short-acting barbiturate. It works by enhancing the action of the neurotransmitter gamma-aminobutyric acid (GABA) in the brain, which results in sedation, hypnosis, and anesthesia. Thiamylal is highly lipid-soluble, which allows it to cross the blood-brain barrier quickly and produce rapid onset of anesthesia.

Medical Uses

In veterinary medicine, thiamylal is used for the induction of anesthesia in dogs and cats, and for the maintenance of anesthesia in horses. It is not commonly used in humans due to the availability of safer and more effective alternatives.

Side Effects

Like other barbiturates, thiamylal can cause a range of side effects, including respiratory depression, cardiovascular depression, and a decrease in blood pressure. It can also cause physical and psychological dependence with prolonged use.

Related Terms

• Barbiturate
• Anesthetic
• Thiophene
• Amyl group
• Carbonyl group
• Gamma-aminobutyric acid
• Blood-brain barrier

Thiamylal Resources
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