Thymulin

Thymulin (also known as Facteur Thymique Serique) is a nonapeptide produced by two distinct epithelial populations in the thymus first described by Bach in 1977. It requires zinc for biological activity. Its peptide sequence is H-Pyr-Ala-Lys-Ser-Gln-Gly-Gly-Ser-Asn-OH.

Function

Thymulin's main role is to stimulate the production of T cells, which are an integral part of the immune system. Thymulin also has a role in T cell maturation and the prevention of autoimmunity.

Clinical significance

Thymulin has been found to be deficient in many conditions, including severe primary immunodeficiency and acquired immunodeficiency syndrome (AIDS). It has also been found to be deficient in aging, which may contribute to the increased susceptibility to infection seen in the elderly.

See also

• Thymus
• T cell
• Immunodeficiency
• AIDS
• Autoimmunity

References

Thymulin Resources
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