Ticarcillin/clavulanic acid
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Ticarcillin/clavulanic acid is a combination antibiotic consisting of Ticarcillin, a penicillin-type antibiotic, and clavulanic acid, a beta-lactamase inhibitor. This combination is used to treat a variety of bacterial infections by inhibiting the synthesis of bacterial cell walls.
Etymology[edit | edit source]
The name "Ticarcillin" is derived from the chemical structure of the drug, which includes a thienylcarboxylic acid moiety. The "clavulanic acid" part of the name comes from the compound's discovery in the organism Streptomyces clavuligerus.
Mechanism of Action[edit | edit source]
Ticarcillin works by inhibiting the final step of bacterial cell wall synthesis by binding to specific penicillin-binding proteins (PBPs) located inside the bacterial cell wall. Clavulanic acid, on the other hand, is a beta-lactamase inhibitor that helps prevent bacterial resistance to ticarcillin by inhibiting the enzyme that many bacteria produce to resist penicillin-type antibiotics.
Uses[edit | edit source]
Ticarcillin/clavulanic acid is used to treat a variety of bacterial infections, including those caused by Pseudomonas aeruginosa, Enterobacter species, and Staphylococcus aureus. It is also used in the treatment of intra-abdominal infections, skin and skin structure infections, and gynecologic infections.
Side Effects[edit | edit source]
Common side effects of ticarcillin/clavulanic acid include diarrhea, nausea, and vomiting. More serious side effects can include allergic reactions, blood disorders, and seizures.
Related Terms[edit | edit source]
- Antibiotic
- Bacterial cell wall
- Beta-lactamase
- Penicillin-binding protein
- Pseudomonas aeruginosa
- Enterobacter
- Staphylococcus aureus
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