Ticarcillin
Information about Ticarcillin[edit source]
Ticarcillin is an extended-spectrum carboxypenicillin antibiotic and is used to treat moderate-to-severe infections due to susceptible organisms.
Liver safety of Ticarcillin[edit source]
Ticarcillin has been linked with idiosyncratic liver injury, but only rarely and as isolated case reports.
Mechanism of action of Ticarcillin[edit source]
Ticarcillin (tye" kar sil' in) is a fourth generation, extended-spectrum penicillin antibiotic which is used for moderate-to-severe infections caused by susceptible gram positive and gram negative agents.
- The extended spectrum of ticarcillin makes it an appropriate agent in therapy of Pseudomonas aeruginosa.
- Ticarcillin also has extended activity against some Enterobacter and Proteus species.
- Ticarcillin has activity against most of the agents that are sensitive to natural penicillins, but is often less active. Ticarcillin is resistant to inactivation by many, but not all beta-lactamases.
Dosage and administration for Ticarcillin[edit source]
Ticarcillin is available in parenteral forms generically and under the name Ticar and is usually given in doses of 200 to 300 mg/kg per day in divided doses intravenously every 4 to 6 hours. Currently it is almost always given in combination with clavunalic acid to increase efficacy against beta-lactamase producing penicillin-resistant bacteria.
Side effects of Ticarcillin[edit source]
Common side effects include nausea, diarrhea, dizziness, headache, rash and hypersensitivity reactions.
Penicillin antibiotics[edit source]
- penicillins first generation (natural penicillins)
- penicillins second generation (penicillinase-resistant penicillins)
- penicillins third generation (aminopenicillins)
- see also amoxicillin-clavulanate
- penicillins fourth generation (extended-spectrum penicillins)
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