Nafcillin
Information about Nafcillin[edit source]
Nafcillin is a parenteral, second generation penicillinase-resistant penicillin antibiotic used largely to treat moderate to severe staphylococcal infections.
Liver safety of Nafcillin[edit source]
Nafcillin has been linked to rare occurrences of clinically apparent, idiosyncratic liver injury.
Mechanism of action of Nafcillin[edit source]
Nafcillin (naf sil' in) is a second generation penicillin that is highly resistant to inactivation by penicillinases and is used to treat moderate-to-severe bacterial infections caused by penicillinase-producing bacteria.
FDA approval information for Nafcillin[edit source]
Nafcillin was approved for use in the United States in 1970 and is still widely used to treat severe staphylococcal infections. To reduce development of drug-resistant bacteria, nafcillin is recommended to treat or prevent only infections that are proven or suspected to be caused by penicillinase-producing susceptible bacteria.
Dosage and administration for Nafcillin[edit source]
Nafcillin is available in multiple generic forms as solutions or powders for intravenous or intramuscular use in 1 or 2 grams per vial. Oral formulations have been developed and are available in some countries. The recommended dose for parenteral use is 1 to 2 grams every 4 to 6 hours for 5 to 30 days depending upon the type and severity of infection. The oral dose is 500 mg to 1 gram four times daily.
Side effects of Nafcillin[edit source]
Common side effects include nausea, diarrhea, dyspepsia, headache, fatigue, urticaria, skin rash and allergic reactions.
Penicillin antibiotics[edit source]
- penicillins first generation (natural penicillins)
- penicillins second generation (penicillinase-resistant penicillins)
- penicillins third generation (aminopenicillins)
- see also amoxicillin-clavulanate
- penicillins fourth generation (extended-spectrum penicillins)
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