Piperacillin

Information about Piperacillin

Piperacillin is an extended spectrum ureidopenicillin and is used to treat moderate-to-severe infections due to susceptible organisms.

Liver safety of Piperacillin

Piperacillin has been linked with idiosyncratic liver injury, but only rarely and in isolated case reports.

Mechanism of action of Piperacillin

Piperacillin (pi" per a sil' in) is a fourth generation, extended spectum penicillin which is used for moderate-to-severe infections caused by susceptible agents, such as (but not limited to) Escherichia coli, Hemophilis influenzae, Listeria monocytogenesis, Neisseria gonorrhoeae, Proteus mirabilis, Salmonella, Shigella, Staphylococcus aureus (non-penicillinase producing), Staphylococcus epidermidis, and Streptococcus pneumoniae. Piperacillin was approved for use in the United States in 1981 and is generally reserved for severe infections requiring parenteral therapy.

Dosage and administration for Piperacillin

Piperacillin is available in parenteral form (intramuscular and intravenous) generically and under the trade name Pipracil. Piperacillin is often combined with a beta lactamase inhibitor (tazobactam) to prevent bacterial resistance. The recommended regimen is 2 to 4 grams daily in divided doses given every 4 to 6 hours usually for 5 to 7 days.

Side effects of Piperacillin

Common side effects include headache, dizziness, nausea, diarrhea, constipation, skin rash and hypersensitivity reactions.

Penicillin antibiotics

• penicillins first generation (natural penicillins)
  • benzathine penicillin, procaine penicillin, penicillin g, penicillin v, penicillin vk

• penicillins second generation (penicillinase-resistant penicillins)
  • cloxacillin, dicloxacillin, flucloxacillin, methicillin, nafcillin, oxacillin

• penicillins third generation (aminopenicillins)
  • amoxicillin, ampicillin, ampicillin-sulbactam, bacampicillin, pivampicillin
• see also amoxicillin-clavulanate

• penicillins fourth generation (extended-spectrum penicillins)
  • carbenicillin, mezlocillin, piperacillin, piperacillin-tazobactam, ticarcillin, ticarcillin-clavulanate

• Dailymed label info on Piperacillin
• FDA Piperacillin

Piperacillin Resources
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