Titin
Titin, also known as connectin, is a protein that in humans is encoded by the TTN gene. It is the largest known protein and plays a key role in muscle contraction.
Structure[edit | edit source]
Titin is a giant protein, greater than 1 µm in length, that functions as a molecular spring which is responsible for the passive elasticity of muscle. It is composed of 244 individually folded protein domains connected by unstructured peptide sequences. These domains are organized into a series of repeating structural motifs.
Function[edit | edit source]
Titin is a critical component of the sarcomere, contributing to its assembly and structure, and its elasticity. It connects the Z line to the M line in the sarcomere. The protein functions as a molecular spring which is responsible for the passive elasticity of muscle.
Clinical significance[edit | edit source]
Mutations in this gene are associated with idiopathic dilated cardiomyopathy (IDC) and familial hypertrophic cardiomyopathy (FHC).
See also[edit | edit source]
References[edit | edit source]
External links[edit | edit source]
- TTN gene at NCBI
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Credits:Most images are courtesy of Wikimedia commons, and templates Wikipedia, licensed under CC BY SA or similar.Contributors: Prab R. Tumpati, MD