Toker cell

Toker cells are a type of epithelial cell found in the human body. They were first described by Claudio D. Toker in 1970. Toker cells are typically found in the nipple and areola regions of the human breast. They are considered to be precursors of Paget's disease of the breast, a rare type of cancer that outwardly may have the appearance of eczema, with skin changes involving the nipple of the breast.

Characteristics[edit | edit source]

Toker cells are clear cells, meaning they have a clear cytoplasm when viewed under a microscope. They are typically larger than the surrounding keratinocytes and are found in the epidermis, the outermost layer of the skin. Toker cells have a round shape and a large, round nucleus. They are often found in clusters.

Clinical significance[edit | edit source]

Toker cells are considered to be precursors to Paget's disease of the breast. This disease is a rare type of breast cancer that begins in the milk ducts and spreads to the skin of the nipple and areola. The presence of Toker cells can be an early indicator of this disease.

Research[edit | edit source]

Research into Toker cells is ongoing. Studies have suggested that these cells may also be present in other areas of the body, such as the vulva. Further research is needed to fully understand the role of Toker cells in the development of cancer.