Travoprost

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Travoprost

Travoprost is a synthetic prostaglandin analogue used in the treatment of glaucoma, a condition that increases pressure in the eyes and leads to vision loss. It is marketed under the brand name Travatan and Travatan Z by Alcon, a division of Novartis.

Pharmacology

Travoprost is a prodrug that is metabolized in the eye to its active form. The active metabolite, a prostaglandin F2α analogue, increases the outflow of aqueous humor from the eye, thereby reducing intraocular pressure. This mechanism of action is different from other classes of glaucoma medications such as beta blockers and carbonic anhydrase inhibitors, which decrease the production of aqueous humor.

Clinical Use

Travoprost is indicated for the reduction of elevated intraocular pressure in patients with open-angle glaucoma or ocular hypertension who are intolerant of or insufficiently responsive to other intraocular pressure lowering medications. It is administered as an ophthalmic solution (eye drops).

Side Effects

Common side effects of Travoprost include ocular hyperemia (red eyes), ocular discomfort, visual disturbance, ocular pruritus (itchy eyes), and growth of eyelashes. Less common but more serious side effects include macular edema and uveitis.

See Also

• Glaucoma
• Prostaglandin analogue
• Intraocular pressure
• Ocular hypertension

References

• PubChem: Travoprost
• Drugs.com: Travoprost
• MedlinePlus: Travoprost