Trifluoromethylphenylpiperazine

Trifluoromethylphenylpiperazine (TFMPP) is a psychoactive drug and research chemical of the piperazine chemical class. It produces entactogenic, anxiogenic, and nootropic effects, and is structurally related to the drugs quinpirole and 1-benzylpiperazine (BZP).

Chemistry

TFMPP is a derivative of piperazine, a six-membered ring with two nitrogen atoms at opposite points in the ring. The trifluoromethylphenyl group is attached to one of these nitrogen atoms. The term "trifluoromethyl" refers to a functional group in organic chemistry that consists of three fluorine atoms attached to a carbon atom. The "phenyl" part of the name refers to the phenyl ring, a six-membered carbon ring with five hydrogen atoms and one carbon atom attached to the trifluoromethyl group.

Pharmacology

TFMPP acts as a non-selective serotonin receptor agonist, meaning it activates multiple types of receptors for the neurotransmitter serotonin in the brain. It has been found to be particularly active at the 5-HT1A and 5-HT2A receptors. This activity at the serotonin receptors is thought to be responsible for its psychoactive effects.

Effects

The effects of TFMPP can vary greatly depending on the dose, the individual's body chemistry, and the presence of other drugs. At lower doses, it can produce feelings of euphoria, increased energy, and enhanced sensory perception. At higher doses, it can cause anxiety, restlessness, and hallucinations. Some users have reported experiencing a "hangover" effect after the drug wears off, including feelings of depression and lethargy.

Legal Status

The legal status of TFMPP varies by country. In some countries, it is a controlled substance, while in others it is legal to possess for personal use. It is important to note that even in countries where TFMPP is legal, it may still be illegal to sell or distribute the drug.

See Also

• Piperazine
• Serotonin receptor
• Psychoactive drug