Trimipramin

Trimipramin

Trimipramine is a tricyclic antidepressant (TCA) primarily used in the treatment of depression. It can also be used for the treatment of insomnia and anxiety disorders. Trimipramine works by inhibiting the reuptake of certain neurotransmitters in the brain, which helps to balance mood and alleviate symptoms of depression and anxiety.

Pharmacology

Trimipramine acts primarily as a serotonin and norepinephrine reuptake inhibitor, meaning it increases the levels of these neurotransmitters in the brain by preventing their reabsorption into the pre-synaptic cell. This results in an increase in the concentration of these neurotransmitters in the synaptic cleft, which leads to increased neurotransmission.

Trimipramine also has strong antihistamine effects, which can lead to sedation, a common side effect. It also has anticholinergic properties, which can lead to side effects such as dry mouth, constipation, and blurred vision.

Clinical Use

Trimipramine is primarily used in the treatment of depression, particularly where sedation is required. It is also used off-label for the treatment of insomnia and certain anxiety disorders.

Side Effects

Common side effects of trimipramine include drowsiness, dry mouth, constipation, blurred vision, and weight gain. More serious side effects can include cardiovascular effects such as tachycardia and hypotension, as well as mental status changes such as confusion and hallucinations.

See Also

• Tricyclic antidepressant
• Serotonin
• Norepinephrine
• Antidepressant