Tyloxapol

Tyloxapol is a nonionic liquid polymer of the alkyl aryl polyether alcohol type. It is used in medicine for its surfactant properties, particularly in the treatment of respiratory distress syndrome (RDS) in newborns.

History

Tyloxapol was first synthesized in the 1960s and has been used in various medical applications since then. It was initially used as a detergent and emulsifier in the pharmaceutical industry, but its surfactant properties soon led to its use in the treatment of respiratory conditions.

Medical Uses

Tyloxapol is primarily used in the treatment of RDS in newborns. RDS is a condition that affects premature babies, causing difficulty in breathing due to the lack of a certain type of surfactant in the lungs. Tyloxapol acts as a substitute for this missing surfactant, reducing the surface tension in the alveoli and allowing the lungs to expand more easily.

In addition to its use in RDS, Tyloxapol is also used in the treatment of chronic obstructive pulmonary disease (COPD) and asthma. It is used as a mucolytic agent, helping to break down and remove mucus from the lungs.

Pharmacology

Tyloxapol works by reducing the surface tension in the lungs, allowing them to expand more easily. It is a nonionic surfactant, meaning it does not carry a charge and therefore does not interact with the body's natural electrical fields. This makes it less likely to cause side effects or interact with other medications.

Side Effects

As with any medication, Tyloxapol can cause side effects. These can include coughing, wheezing, and shortness of breath. In rare cases, it can cause allergic reactions, including rash, itching, and swelling.

See Also

• Surfactant
• Respiratory distress syndrome
• Chronic obstructive pulmonary disease
• Asthma