UGT1A6

Ideogram human chromosome 2

UGT1A6

UGT1A6 is an enzyme that in humans is encoded by the UGT1A6 gene. This gene is a member of the UDP-glucuronosyltransferase family. The UGT1A6 enzyme is involved in the glucuronidation of various endogenous compounds and xenobiotics, including bilirubin, steroids, and environmental toxins.

Function

The UGT1A6 enzyme catalyzes the transfer of the glucuronic acid moiety from uridine diphosphoglucuronic acid to a variety of substrates, making them more water-soluble and facilitating their excretion from the body. This process is crucial for the detoxification and elimination of potentially harmful compounds.

Clinical Significance

Genetic variations in the UGT1A6 gene can affect the activity of the enzyme, leading to differences in drug metabolism and susceptibility to certain diseases. Polymorphisms in UGT1A6 have been associated with altered drug response and toxicity in individuals.

Regulation

The expression of the UGT1A6 gene is regulated by various factors, including hormones, environmental cues, and genetic variations. Understanding the regulatory mechanisms of UGT1A6 can provide insights into how its activity is modulated in different physiological and pathological conditions.