UGT2B15

Ideogram human chromosome 4

UGT2B15

UGT2B15 is an enzyme that in humans is encoded by the UGT2B15 gene. This gene is a member of the UDP-glucuronosyltransferase family. The UGT2B15 enzyme is involved in the glucuronidation of various endogenous compounds and xenobiotics, including steroids and drugs.

Function

The UGT2B15 enzyme catalyzes the transfer of the glucuronic acid moiety from uridine diphosphoglucuronic acid to a diverse range of substrates. This process is a major pathway for the metabolism of many drugs and endogenous compounds in the body.

Clinical Significance

Genetic variations in the UGT2B15 gene can affect the activity of the enzyme, leading to differences in drug metabolism and response to medications. Studies have shown that certain polymorphisms in the UGT2B15 gene may influence an individual's susceptibility to adverse drug reactions or alter drug efficacy.

Regulation

The expression of the UGT2B15 gene can be influenced by various factors, including hormonal regulation and environmental exposures. Understanding the regulation of this gene is important for predicting drug interactions and optimizing therapeutic outcomes.

See also

• UDP-glucuronosyltransferase
• Drug metabolism
• Pharmacogenetics