Ulegyria

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A type of brain injury



Ulegyria is a form of brain injury characterized by scarring and atrophy of the cerebral cortex, particularly affecting the gyri. This condition is often associated with perinatal hypoxic-ischemic events, where the brain is deprived of adequate oxygen supply during birth.

Pathophysiology[edit | edit source]

Ulegyria results from a lack of oxygen (hypoxia) and blood flow (ischemia) to the brain, typically occurring around the time of birth. This leads to selective vulnerability of the cortical neurons, particularly in the depths of the sulci, resulting in a characteristic "mushroom-shaped" appearance of the gyri. The condition is often associated with cerebral palsy and other neurodevelopmental disorders.

Diagram showing the gyri and sulci of the brain.

Clinical Features[edit | edit source]

Individuals with ulegyria may present with a variety of neurological symptoms, including seizures, motor deficits, and cognitive impairments. The severity of symptoms can vary widely depending on the extent and location of the brain injury.

Diagnosis[edit | edit source]

Diagnosis of ulegyria is typically made through neuroimaging techniques such as magnetic resonance imaging (MRI), which can reveal the characteristic cortical scarring and atrophy. MRI may show the "mushroom-shaped" gyri and other structural abnormalities in the brain.

Histological image of brain tissue showing damage similar to that seen in ulegyria.

Treatment[edit | edit source]

There is no specific treatment for ulegyria, and management focuses on addressing the symptoms and complications associated with the condition. This may include antiepileptic drugs for seizure control, physical therapy for motor deficits, and educational interventions for cognitive impairments.

Prognosis[edit | edit source]

The prognosis for individuals with ulegyria varies depending on the severity of the brain injury and the presence of associated conditions. Early intervention and supportive therapies can improve outcomes for affected individuals.

Related Conditions[edit | edit source]

Ulegyria is often discussed in the context of other conditions resulting from perinatal brain injury, such as polymicrogyria and periventricular leukomalacia.

Image showing polymicrogyria, a condition that can be associated with ulegyria.

Related pages[edit | edit source]

References[edit | edit source]

  • Volpe, J. J. (2008). Neurology of the Newborn. 5th ed. Philadelphia: Saunders Elsevier.
  • Barkovich, A. J. (2012). Pediatric Neuroimaging. 5th ed. Philadelphia: Lippincott Williams & Wilkins.
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Contributors: Prab R. Tumpati, MD