Uloric

What is Uloric?[edit | edit source]

Uloric (Febuxostat) is a xanthine oxidase (XO) inhibitor used for the chronic management of hyperuricemia in patients with gout.

Febuxostat

Febuxostat molecule ball

What are the uses of this medicine?[edit | edit source]

Uloric (Febuxostat) is a prescription medicine called a xanthine oxidase (XO) inhibitor, used to lower blood uric acid levels in adults with gout.

Limitations of Use:

ULORIC is not recommended for the treatment of asymptomatic hyperuricemia.

How does this medicine work?[edit | edit source]

Febuxostat (fe bux' oh stat) is a nonpurine inhibitor of xanthine oxidase that shares no structural homology to allopurinol or to hypoxanthine. Therapy with febuxostat leads to lowering of serum uric acid levels within a few weeks, and chronic therapy has been shown to decrease uric acid levels into target levels of <6 mg/dL and to decrease acute gouty attacks.

Who Should Not Use this medicine ?[edit | edit source]

This medicine cannot be used in patients who:

take Azathioprine (Azasan®, Imuran®)
take Mercaptopurine (Purinethol®)
take Theophylline (Theo-24®, Elixophyllin®, Theochron®, Theolair®, Uniphyl®)

What drug interactions can this medicine cause?[edit | edit source]

ULORIC is contraindicated in patients being treated with azathioprine, mercaptopurine, or theophylline.
No data are available regarding the safety of ULORIC during cytotoxic chemotherapy.

Is this medicine FDA approved?[edit | edit source]

Febuxostat was approved for medical use in the European Union in 2008 and in the United States in 2009.

How should this medicine be used?[edit | edit source]

Recommended dosage:

For treatment of hyperuricemia in patients with gout, ULORIC is recommended at 40 mg or 80 mg once daily.
The recommended starting dose of ULORIC is 40 mg once daily. For patients who do not achieve a serum uric acid (sUA) less than 6 mg per dL after 2 weeks with 40 mg, ULORIC 80 mg is recommended.
No dose adjustment is necessary when administering ULORIC to patients with mild to moderate renal or hepatic impairment.

Administration:

Take ULORIC exactly as your healthcare provider tells you to take it.
ULORIC can be taken with or without food.
ULORIC can be taken with antacids.
Your gout may flare up when you start taking ULORIC, do not stop taking your ULORIC even if you have a flare. Your healthcare provider may give you other medicines to help prevent your gout flares.
Your healthcare provider may do certain tests while you take ULORIC.

What are the dosage forms and brand names of this medicine?[edit | edit source]

This medicine is available in fallowing doasage form:

As Tablet: 40 mg, 80 mg.

This medicine is available in fallowing brand namesː

ULORIC

What side effects can this medication cause?[edit | edit source]

The most common side effects of this medicine include:

liver problems
nausea
gout flares
joint pain
rash

This medicine may cause serious side effects, including:

Heart problems

What special precautions should I follow?[edit | edit source]

After initiation of ULORIC, an increase in gout flares is frequently observed. This increase is due to reduction in serum uric acid levels. If a gout flare occurs during treatment, ULORIC need not be discontinued. Prophylactic therapy (i.e., non-steroidal anti-inflammatory drug (NSAID) or colchicine upon initiation of treatment) may be beneficial for up to six months.
A higher rate of cardiovascular thromboembolic events was observed in patients treated with ULORIC than allopurinol in clinical trials. Monitor for signs and symptoms of MI and stroke.
Transaminase elevations have been observed in ULORIC-treated patients. Monitor liver function tests periodically.

What to do in case of emergency/overdose?[edit | edit source]

Symptoms of overdosage may include:

No overdose of ULORIC was reported in clinical studies.

Treatment of overdosage:

Patients should be managed by symptomatic and supportive care should there be an overdose.

Can this medicine be used in pregnancy?[edit | edit source]

There are no adequate and well-controlled studies in pregnant women.
ULORIC should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.

Can this medicine be used in children?[edit | edit source]

Safety and effectiveness in pediatric patients under 18 years of age have not been established.

What are the active and inactive ingredients in this medicine?[edit | edit source]

Active Ingredient: febuxostat
Inactive ingredients include: lactose monohydrate, microcrystalline cellulose, hydroxypropyl cellulose, sodium croscarmellose, silicon dioxide, magnesium stearate, and Opadry II, green

Who manufactures and distributes this medicine?[edit | edit source]

Distributed by Takeda Pharmaceuticals America, Inc. Deerfield, IL

ULORIC® is a registered trademark of Teijin Pharma Limited and used under license by Takeda Pharmaceuticals America, Inc.

What should I know about storage and disposal of this medication?[edit | edit source]

Store ULORIC between 59°F - 86°F (15°C - 30°C).
Keep ULORIC out of the light.

Uloric Resources
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