Hyperuricemia
Hyperuricemia[edit | edit source]
Introduction[edit | edit source]
Hyperuricemia refers to a condition characterized by elevated blood concentrations of uric acid, a waste product in the blood that can result from the breakdown of purines.
Pathophysiology[edit | edit source]
Uric acid is typically filtered out of the blood by the kidneys and excreted in urine. Hyperuricemia occurs when there is an increase in uric acid production, a decrease in uric acid excretion, or a combination of both.
Causes[edit | edit source]
Common causes of hyperuricemia include:
- Genetic predisposition
- High-purine diet
- Obesity
- Certain medications (e.g., diuretics)
- Renal impairment
- Diseases like leukemia or psoriasis
Symptoms and Complications[edit | edit source]
While hyperuricemia itself is often asymptomatic, it can lead to serious complications like:
- Gout
- Kidney stones
- Renal dysfunction
Diagnosis[edit | edit source]
Diagnosis of hyperuricemia is usually made through blood tests that measure uric acid levels.
Treatment[edit | edit source]
Treatment focuses on reducing uric acid levels through:
- Medications (e.g., allopurinol, febuxostat)
- Dietary modifications to reduce purine intake
- Weight loss and lifestyle changes
- Increased fluid intake
Prevention[edit | edit source]
Preventive measures include:
- Maintaining a healthy weight
- Avoiding excessive alcohol consumption
- Limiting intake of high-purine foods
- Staying well-hydrated
Epidemiology[edit | edit source]
Hyperuricemia is a common condition, particularly among men and postmenopausal women, and its prevalence has been increasing worldwide.
See Also[edit | edit source]
References[edit | edit source]
External Links[edit | edit source]
| Hyperuricemia Resources | |
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