Uvadex

Uvadex (also known as Methoxsalen) is a medication used in the treatment of psoriasis, eczema, vitiligo, and some cutaneous lymphomas in conjunction with exposing the skin to UVA light from lamps or sunlight. Methoxsalen modifies the way skin cells receive the UVA radiation, allegedly clearing up the disease.

Mechanism of Action

Uvadex works by intercalating into DNA, forming covalent links with adjacent pyrimidine bases, primarily thymine. Upon exposure to UVA light, it forms monoadducts and then crosslinks between the two strands of DNA, inhibiting DNA synthesis and cell division. The exact mechanism of action in treating psoriasis is not well understood.

Uses

Uvadex is used in PUVA therapy (psoralen + UVA), where it is combined with UVA exposure to treat conditions such as psoriasis, eczema, and vitiligo. It is also used in the treatment of cutaneous T-cell lymphoma, a type of skin cancer.

Side Effects

Common side effects of Uvadex include nausea, itching, and redness of the skin. Severe side effects may include an increased risk of skin cancer, cataracts, and aging of the skin.

Contraindications

Uvadex should not be used in individuals with a history of light-sensitive disease conditions, liver disease, or with known allergies to psoralen compounds.

See Also

• Psoriasis
• Eczema
• Vitiligo
• Cutaneous T-cell lymphoma
• PUVA therapy

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