VSX2
VSX2[edit | edit source]
VSX2 is a gene that encodes a transcription factor involved in the development and function of the visual system. It is also known as Visual System Homeobox 2 or Chx10. The VSX2 gene is found in various species, including humans, mice, and zebrafish.
Structure[edit | edit source]
The VSX2 gene is located on chromosome 14 in humans and consists of several exons. It encodes a protein that contains a homeodomain, which is a DNA-binding domain that allows the protein to bind to specific DNA sequences. This homeodomain is crucial for the transcriptional regulation of target genes involved in eye development.
Function[edit | edit source]
VSX2 plays a critical role in the development of the eye and the maintenance of its function. It is primarily expressed in the developing retina, where it regulates the differentiation of retinal progenitor cells into various cell types, including photoreceptors, bipolar cells, and Müller glia.
During embryonic development, VSX2 is involved in the specification of retinal cell types. It promotes the formation of retinal progenitor cells and inhibits their differentiation into non-retinal cell types. Additionally, VSX2 is required for the proper development of the optic nerve and the establishment of retinal circuitry.
In the adult retina, VSX2 continues to be expressed in specific cell types, such as bipolar cells and Müller glia. It is involved in the maintenance of these cells and their function in visual signal processing.
Clinical Significance[edit | edit source]
Mutations in the VSX2 gene have been associated with various eye disorders, including microphthalmia, anophthalmia, and congenital cataracts. These conditions result from abnormal eye development during embryogenesis. Additionally, mutations in VSX2 have been linked to retinal degenerative diseases, such as retinitis pigmentosa.
Understanding the role of VSX2 in eye development and function is crucial for the development of potential therapeutic strategies for these eye disorders. Further research is needed to elucidate the precise mechanisms by which VSX2 regulates gene expression and cellular differentiation in the visual system.
See Also[edit | edit source]
References[edit | edit source]
<references>
Search WikiMD
Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro / Zepbound) available.
Advertise on WikiMD
|
WikiMD's Wellness Encyclopedia |
| Let Food Be Thy Medicine Medicine Thy Food - Hippocrates |
Translate this page: - East Asian
中文,
日本,
한국어,
South Asian
हिन्दी,
தமிழ்,
తెలుగు,
Urdu,
ಕನ್ನಡ,
Southeast Asian
Indonesian,
Vietnamese,
Thai,
မြန်မာဘာသာ,
বাংলা
European
español,
Deutsch,
français,
Greek,
português do Brasil,
polski,
română,
русский,
Nederlands,
norsk,
svenska,
suomi,
Italian
Middle Eastern & African
عربى,
Turkish,
Persian,
Hebrew,
Afrikaans,
isiZulu,
Kiswahili,
Other
Bulgarian,
Hungarian,
Czech,
Swedish,
മലയാളം,
मराठी,
ਪੰਜਾਬੀ,
ગુજરાતી,
Portuguese,
Ukrainian
Medical Disclaimer: WikiMD is not a substitute for professional medical advice. The information on WikiMD is provided as an information resource only, may be incorrect, outdated or misleading, and is not to be used or relied on for any diagnostic or treatment purposes. Please consult your health care provider before making any healthcare decisions or for guidance about a specific medical condition. WikiMD expressly disclaims responsibility, and shall have no liability, for any damages, loss, injury, or liability whatsoever suffered as a result of your reliance on the information contained in this site. By visiting this site you agree to the foregoing terms and conditions, which may from time to time be changed or supplemented by WikiMD. If you do not agree to the foregoing terms and conditions, you should not enter or use this site. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates Wikipedia, licensed under CC BY SA or similar.
Contributors: Prab R. Tumpati, MD
