VCJD

vCJD or variant Creutzfeldt-Jakob disease is a rare and fatal human neurodegenerative condition. It is classified as a transmissible spongiform encephalopathy (TSE), also known as prion diseases, because it is believed to be caused by prions.

Etiology

vCJD is believed to be caused by consumption of products from cattle infected with bovine spongiform encephalopathy (BSE), a similar prion disease in cattle. The exact mechanism of transmission is not fully understood, but it is believed that prions from the infected beef products somehow cross the species barrier and cause disease in humans.

Symptoms

The symptoms of vCJD are similar to other forms of Creutzfeldt-Jakob disease (CJD), but there are some differences. Early symptoms include psychiatric symptoms such as depression and anxiety, followed by neurological symptoms such as unsteadiness, difficulty walking, and involuntary movements. As the disease progresses, patients may experience dementia and other cognitive impairments.

Diagnosis

Diagnosis of vCJD is challenging because the symptoms are similar to other neurological disorders. However, certain tests can help in the diagnosis, including electroencephalography (EEG), MRI, and testing for the presence of 14-3-3 protein in the cerebrospinal fluid. A definitive diagnosis can only be made by examining brain tissue after death.

Treatment

There is currently no cure for vCJD. Treatment is focused on relieving symptoms and making the patient as comfortable as possible. This may include medications to control symptoms, physical therapy to help with mobility issues, and counseling to help with mental health issues.

Epidemiology

vCJD was first identified in the United Kingdom in the 1990s, during an outbreak of BSE. Since then, cases have been reported in several other countries, but the disease remains rare. The exact number of cases is difficult to determine because of the challenges in diagnosing the disease.

See also

• Prion
• Bovine spongiform encephalopathy
• Creutzfeldt-Jakob disease

References

VCJD Resources
Need Help Finding a Doctor? Need help finding a doctor or specialist anywhere in the world? Explore our world directory. WikiMD's DocFinder can assist you in locating millions of physicians.	Medical Knowledge Access the latest research - Most recent articles Ongoing trials.

Translate to: East Asian 中文, 日本, 한국어, South Asian हिन्दी, Urdu, বাংলা, తెలుగు, தமிழ், ಕನ್ನಡ,
Southeast Asian Indonesian, Vietnamese, Thai, မြန်မာဘာသာ, European español, Deutsch, français, русский, português do Brasil, Italian, polski