Verosudil

Verosudil is a pharmacological agent that is primarily used in the treatment of glaucoma. It belongs to the class of Rho kinase inhibitors, which are known for their ability to reduce intraocular pressure by improving the outflow of aqueous humor in the eye.

Mechanism of Action

Verosudil works by inhibiting the activity of Rho kinase, an enzyme that plays a crucial role in the regulation of the tone of smooth muscle and cell shape. By inhibiting this enzyme, Verosudil causes relaxation of the trabecular meshwork and Schlemm's canal, two structures in the eye that are involved in the drainage of aqueous humor. This results in an increased outflow of aqueous humor and a subsequent reduction in intraocular pressure.

Clinical Use

Verosudil is used in the treatment of open-angle glaucoma and ocular hypertension. It is often used when other treatments have failed or are not tolerated. The drug is administered topically as eye drops.

Side Effects

Common side effects of Verosudil include conjunctival hyperemia (redness of the eye), corneal verticillata (deposits in the cornea), and instillation site pain. Less common side effects include blurred vision, dry eye, and allergic reactions.

Pharmacokinetics

After topical administration, Verosudil is rapidly absorbed into the systemic circulation. The drug is metabolized in the liver and excreted in the urine.

See Also

• Rho kinase inhibitors
• Glaucoma
• Ocular hypertension