Viridicatumtoxin B
Viridicatumtoxin B is a tetracycline-class antibiotic produced by the fungus Penicillium citreonigrum. It is a potent inhibitor of bacterial protein synthesis, and has been studied for its potential use in the treatment of bacterial infections.
Structure and Synthesis[edit | edit source]
Viridicatumtoxin B is a macrolide with a 12-membered ring structure. It is synthesized by the fungus Penicillium citreonigrum through a series of enzyme-catalyzed reactions. The biosynthetic pathway involves the formation of a polyketide chain, which is then cyclized to form the macrolide ring. The final steps involve the addition of a sugar moiety and a methyl group to complete the structure.
Mechanism of Action[edit | edit source]
Viridicatumtoxin B inhibits bacterial protein synthesis by binding to the 30S ribosomal subunit, preventing the aminoacyl-tRNA from attaching to the A site. This blocks the elongation of the polypeptide chain, leading to the termination of protein synthesis.
Potential Medical Uses[edit | edit source]
Due to its potent antibacterial activity, Viridicatumtoxin B has been studied for its potential use in the treatment of bacterial infections. However, further research is needed to determine its safety and efficacy in humans.
See Also[edit | edit source]
References[edit | edit source]
Search WikiMD
Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro / Zepbound) available.
Advertise on WikiMD
WikiMD's Wellness Encyclopedia |
Let Food Be Thy Medicine Medicine Thy Food - Hippocrates |
Translate this page: - East Asian
中文,
日本,
한국어,
South Asian
हिन्दी,
தமிழ்,
తెలుగు,
Urdu,
ಕನ್ನಡ,
Southeast Asian
Indonesian,
Vietnamese,
Thai,
မြန်မာဘာသာ,
বাংলা
European
español,
Deutsch,
français,
Greek,
português do Brasil,
polski,
română,
русский,
Nederlands,
norsk,
svenska,
suomi,
Italian
Middle Eastern & African
عربى,
Turkish,
Persian,
Hebrew,
Afrikaans,
isiZulu,
Kiswahili,
Other
Bulgarian,
Hungarian,
Czech,
Swedish,
മലയാളം,
मराठी,
ਪੰਜਾਬੀ,
ગુજરાતી,
Portuguese,
Ukrainian
WikiMD is not a substitute for professional medical advice. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates Wikipedia, licensed under CC BY SA or similar.
Contributors: Prab R. Tumpati, MD