Vitaxin

Vitaxin (MEDI-523): An Angiogenesis Inhibitor[edit]

Vitaxin (MEDI-523) is a humanized monoclonal antibody designed to target the vascular integrin alpha-v beta-3, playing a significant role in angiogenesis inhibition. With implications for the treatment of various cancers, Vitaxin's development and clinical investigation have underscored its potential therapeutic utility, as well as its safety profile.

Background[edit]

Classification: Humanized monoclonal antibody.
Target: Vascular integrin alpha-v beta-3.

Mechanism of Action[edit]

Vitaxin functions as an antagonist to the vascular integrin alpha-v beta-3. This integrin is central to the process of angiogenesis, or the formation of new blood vessels, which is a crucial process for the growth and survival of tumors^[1].

Therapeutic Applications[edit]

Cancer Treatment: Due to its inhibitory effects on angiogenesis, Vitaxin has been investigated as a therapeutic agent in the management of several cancers. The ability to curtail blood vessel formation can deprive tumors of necessary nutrients, leading to their stagnation or regression.
Rheumatoid Arthritis: In 2002, researchers began exploring the potential of Vitaxin in treating rheumatoid arthritis, a chronic inflammatory condition that can benefit from angiogenesis inhibition^[2].

Developmental Lineage[edit]

Origin: Vitaxin is derived from the mouse antibody LM609.
Successor: Vitaxin served as the developmental precursor for Etaracizumab (MEDI-522), which also targets the same integrin.

Clinical Assessment[edit]

Safety Profile: Clinical studies have demonstrated that Vitaxin is well-tolerated and safe for human administration^[3].
Efficacy: While safe, its therapeutic efficacy for advanced cancers appears to be limited. Further studies are necessary to determine the best applications and patient populations for Vitaxin treatment^[4].

Conclusion[edit]

Vitaxin, as an angiogenesis inhibitor, embodies the potential of targeted therapies in the realm of oncology and other diseases. Its safety profile encourages further investigation into its therapeutic applications, while its developmental lineage has spurred the creation of subsequent compounds, broadening the scope of this class of drugs.

This WikiMD article can only be edited by registered and verified editors. You can log in or register.

↑ Brooks PC, et al. Integrin alpha v beta 3 antagonists promote tumor regression by inducing apoptosis of angiogenic blood vessels. Cell. 1994;79(7):1157-1164.
↑ Feldmann M, Maini RN. Lasker Clinical Medical Research Award. TNF defined as a therapeutic target for rheumatoid arthritis and other autoimmune diseases. Nat Med. 2003;9(10):1245-1250.
↑ Dechantsreiter MA, et al. N-Methylated cyclic RGD peptides as highly active and selective alpha(V)beta(3) integrin antagonists. J Med Chem. 1999;42(16):3033-3040.
↑ Gutheil JC, et al. Targeted antiangiogenic therapy for cancer using Vitaxin: a humanized monoclonal antibody to the integrin alphavbeta3. Clin Cancer Res. 2000;6(8):3056-3061.

Navigation-> Medicine - Wellness - Encyclopedia - Health topics - Diseases - Drugs - Gray's Anatomy - W8MD diet - Ketogenic diet - Recipes

Sponsored Health Resource

W8MD Weight Loss, Sleep & MedSpa

Looking for physician-supervised weight loss, semaglutide, tirzepatide, or GLP-1 receptor agonist options? W8MD helps eligible patients in New York City, Brooklyn, New Jersey, Connecticut, Pennsylvania, Delaware, and greater Philadelphia with medical weight loss, sleep medicine, and long-term maintenance support.

GLP-1 specials: Affordable GLP-1 injections NYC and Philadelphia starting from $29.99/week and up for semaglutide with insurance accepted for qualifying visits, and $45/week and up for tirzepatide with insurance accepted for qualifying visits. Self-pay options start from $59.99/week and up for semaglutide and $69.99/week and up for tirzepatide.

Book a W8MD appointment · View GLP-1 specials

Paid promotional message. Eligibility, pricing, insurance coverage, medication availability, and results vary. Medical evaluation required.

Medical Disclaimer: WikiMD is for informational purposes only and is not a substitute for professional medical advice. Content may be inaccurate or outdated and should not be used for diagnosis or treatment. Always consult your healthcare provider for medical decisions. Verify information with trusted sources such as CDC.gov and NIH.gov. By using this site, you agree that WikiMD is not liable for any outcomes related to its content. See full disclaimer.

Credits:Most images are courtesy of Wikimedia commons, and templates, categories Wikipedia, licensed under CC BY SA or similar.

Translate page: - East Asian 中文, 日本, 한국어, South Asian हिन्दी, தமிழ், తెలుగు, Urdu, ಕನ್ನಡ, Southeast Asian Indonesian, Vietnamese, Thai, မြန်မာဘာသာ, বাংলা
European español, Deutsch, français, Greek, português do Brasil, polski, română, русский, Nederlands, norsk, svenska, suomi, Italian
Middle Eastern & African عربى, Turkish, Persian, Hebrew, Afrikaans, isiZulu, Kiswahili,
Other Bulgarian, Hungarian, Czech, Swedish, മലയാളം, मराठी, ਪੰਜਾਬੀ, ગુજરાતી, Portuguese, Ukrainian

[1] Brooks PC, et al. Integrin alpha v beta 3 antagonists promote tumor regression by inducing apoptosis of angiogenic blood vessels. Cell. 1994;79(7):1157-1164.

[2] Feldmann M, Maini RN. Lasker Clinical Medical Research Award. TNF defined as a therapeutic target for rheumatoid arthritis and other autoimmune diseases. Nat Med. 2003;9(10):1245-1250.

[3] Dechantsreiter MA, et al. N-Methylated cyclic RGD peptides as highly active and selective alpha(V)beta(3) integrin antagonists. J Med Chem. 1999;42(16):3033-3040.

[4] Gutheil JC, et al. Targeted antiangiogenic therapy for cancer using Vitaxin: a humanized monoclonal antibody to the integrin alphavbeta3. Clin Cancer Res. 2000;6(8):3056-3061.

[1]

[2]

[3]

[4]