Vorozole

Vorozole is a nonsteroidal inhibitor of aromatase that is used in the treatment of breast cancer. It is classified as an antiestrogen and is similar in structure and function to anastrozole and letrozole.

Mechanism of Action

Vorozole works by inhibiting the enzyme aromatase, which is responsible for the conversion of androgens (male hormones) into estrogens (female hormones). By blocking this conversion, vorozole effectively reduces the levels of estrogen in the body, which can slow or stop the growth of certain types of breast cancer cells that require estrogen to grow.

Uses

Vorozole is primarily used in the treatment of hormone receptor-positive breast cancer in postmenopausal women. It may also be used in cases where other treatments have failed or are not suitable.

Side Effects

Common side effects of vorozole include hot flashes, nausea, vomiting, and fatigue. Less common but more serious side effects can include bone loss and fractures, hypercholesterolemia, and cardiovascular disease.

Contraindications

Vorozole is contraindicated in premenopausal women and in patients with known hypersensitivity to vorozole or any of its components.

See Also

• Aromatase inhibitor
• Breast cancer
• Hormone therapy

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