WASHC2C

WASHC2C

WASHC2C (WASH Complex Subunit 2C) is a protein that in humans is encoded by the WASHC2C gene. This protein is a part of the WASH complex, which is involved in the regulation of the actin cytoskeleton and plays a crucial role in endosomal trafficking.

Function

The WASH complex is essential for the formation of actin patches on endosomes, which are necessary for the sorting and trafficking of endosomal cargo. The WASHC2C protein, as a component of this complex, contributes to the activation of the Arp2/3 complex, which initiates the nucleation of new actin filaments. This process is vital for various cellular functions, including cell migration, phagocytosis, and signal transduction.

Structure

The WASHC2C protein is composed of several domains that facilitate its interaction with other components of the WASH complex and the actin cytoskeleton. These domains include the WH2 domain, which binds to actin monomers, and the SH3 domain, which mediates protein-protein interactions.

Clinical Significance

Mutations or dysregulation of the WASHC2C gene can lead to defects in endosomal trafficking, which may contribute to various diseases, including neurodegenerative disorders and cancer. Research is ongoing to better understand the specific roles of WASHC2C in these conditions and to explore potential therapeutic targets.

Related Proteins

The WASH complex includes several other proteins, such as WASHC1, WASHC2A, WASHC2B, and WASHC3. These proteins work together to regulate actin dynamics and endosomal trafficking.

Research

Current research on WASHC2C focuses on its role in cellular processes and its potential involvement in disease mechanisms. Studies are being conducted to elucidate the molecular pathways regulated by WASHC2C and to identify how alterations in these pathways contribute to disease.

See Also

• Actin cytoskeleton
• Endosomal trafficking
• Arp2/3 complex
• Cell migration
• Phagocytosis
• Signal transduction
• Neurodegenerative disorders
• Cancer