WAY-166818

WAY-166818 is a nonsteroidal antagonist of the androgen receptor (AR) that was never marketed. It is selective for the AR over other steroid hormone receptors and has been used to elucidate the role of the AR in bone and muscle physiology in scientific research.

Pharmacology

WAY-166818 is a nonsteroidal antagonist of the AR, the biological target of androgens like testosterone and dihydrotestosterone (DHT). It has been found to block the effects of these androgens in bioassays and has been used in scientific research to elucidate the role of the AR in bone and muscle physiology.

Chemistry

WAY-166818, also known as 4-[7-[[2-(4-Methylphenyl)-5,7-dimethyl-2,3-dihydro-1H-pyrrolizin-1-yl]methyl]-2,3-dihydro-1H-pyrrolizin-1-yl]-2-methylbenzonitrile, is a synthetic compound of the pyrrolizine class. It is structurally related to the nonsteroidal AR antagonist bicalutamide, which is used clinically as an antiandrogen in the treatment of prostate cancer.

Research

Research with WAY-166818 has helped to elucidate the role of the AR in bone and muscle physiology. For instance, it has been found that the AR is essential for the maintenance of bone and muscle mass in males, and that androgens and the AR have important roles in the regulation of body composition, muscle mass, and bone density.

See also

• List of investigational sex-hormonal agents
• List of androgen receptor antagonists

External links

• PubChem Compound Summary for CID 9794143, WAY-166818

WAY-166818 Resources
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