WDR12
WDR12 (WD Repeat Domain 12) is a protein that in humans is encoded by the WDR12 gene. This protein is a member of the WD repeat protein family, which is characterized by the presence of WD repeats, a structural motif that facilitates the formation of protein-protein interactions. WDR12 is involved in ribosome biogenesis and is a component of the PeBoW complex, which is essential for the maturation of the 60S ribosomal subunit.
Structure[edit | edit source]
WDR12 contains multiple WD repeats, which are typically 40 amino acids in length and often terminate in a tryptophan-aspartic acid (WD) dipeptide. These repeats form a beta-propeller structure that serves as a platform for protein-protein interactions. The structure of WDR12 allows it to interact with other components of the PeBoW complex, including PES1 and BOP1.
Function[edit | edit source]
WDR12 plays a critical role in the assembly and maturation of the 60S ribosomal subunit. It is part of the PeBoW complex, which is required for the processing of the 32S precursor rRNA into the mature 28S and 5.8S rRNAs. This processing is a crucial step in the production of functional ribosomes, which are essential for protein synthesis in the cell.
Clinical Significance[edit | edit source]
Mutations or dysregulation of WDR12 can lead to defects in ribosome biogenesis, which can have various cellular consequences. Given the fundamental role of ribosomes in protein synthesis, such defects can contribute to diseases, including cancer. Studies have shown that alterations in ribosome biogenesis are associated with tumorigenesis, and components of the ribosome biogenesis pathway, including WDR12, are often found to be dysregulated in cancer cells.
Research[edit | edit source]
Research on WDR12 is ongoing to better understand its role in ribosome biogenesis and its potential implications in disease. Studies are exploring how WDR12 interacts with other proteins in the PeBoW complex and how these interactions are regulated. Additionally, there is interest in targeting the ribosome biogenesis pathway as a therapeutic strategy in cancer, making WDR12 a potential target for drug development.
Also see[edit | edit source]
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