WDR90

WDR90

WDR90 is a protein-coding gene that is also known as WD repeat domain 90. It is located on chromosome 7 in humans and is conserved across various species. The WDR90 gene is involved in several cellular processes and has been linked to certain diseases and disorders.

Gene Structure and Function

The WDR90 gene spans approximately 100 kilobases and consists of 23 exons. It encodes a protein that contains multiple WD40 repeat domains. WD40 repeats are structural motifs found in a wide range of proteins and are involved in protein-protein interactions.

The exact function of WDR90 is not yet fully understood. However, studies have suggested its involvement in DNA repair and maintenance of genomic stability. It has been shown to interact with other proteins involved in DNA damage response pathways, suggesting a role in DNA repair mechanisms.

Clinical Significance

Mutations in the WDR90 gene have been associated with certain diseases and disorders. For example, a specific mutation in WDR90 has been linked to a rare genetic disorder called Trichothiodystrophy (TTD). TTD is characterized by brittle hair, intellectual disability, and various other symptoms. The exact mechanism by which WDR90 mutations lead to TTD is still under investigation.

Furthermore, alterations in the expression of WDR90 have been observed in certain types of cancer. Studies have shown that WDR90 expression is downregulated in some cancer cells, suggesting a potential tumor-suppressive role. Further research is needed to fully understand the implications of WDR90 in cancer development and progression.

See Also

• DNA repair
• Genomic stability
• Trichothiodystrophy
• Cancer

External Links

• WDR90 Gene at NCBI
• WDR90 Protein at UniProt