WIN 35428

WIN 35428 is a stimulant drug by Winthrop Laboratories that has been used in scientific research. It acts as a potent and selective dopamine reuptake inhibitor (DRI), with an IC50 value of 2.3 nM, making it around one third as potent as cocaine as a DRI, but with negligible activity as a serotonin reuptake inhibitor (SRI).

Chemistry

WIN 35428, also known as 2β-Propanoyl-3β-(4-tolyl)-tropane or CFT, is a synthetic analog of cocaine and is often used in research to better understand the properties of the dopamine transporter (DAT). The structure of WIN 35428 is similar to that of cocaine, except that the benzoyl ester has been replaced with a propanoyl ester, and the methyl ester has been replaced with a tolyl group.

Pharmacology

WIN 35428 is a potent and selective inhibitor of the dopamine transporter (DAT), which is responsible for the reuptake of dopamine in the synapse. By inhibiting this transporter, WIN 35428 increases the amount of dopamine available in the synapse, leading to increased dopaminergic activity. This is thought to be the primary mechanism by which WIN 35428 exerts its stimulant effects.

Research Use

Due to its potent and selective inhibition of the dopamine transporter, WIN 35428 is often used in scientific research to study the role of this transporter in various processes, including neurotransmission, drug addiction, and Parkinson's disease. It is also used as a radiolabeled tracer in positron emission tomography (PET) studies of the dopamine system.

See Also

• Dopamine reuptake inhibitor
• Cocaine
• Dopamine transporter
• Stimulant