WIN-35428

Phenyltropane 11b - WIN 35428

WIN-35428 (also known as CFT) is a psychoactive drug and research chemical of the phenethylamine and amphetamine chemical classes. It acts as a potent and selective dopamine reuptake inhibitor (DRI), making it of significant interest for scientific studies related to the dopamine system in the brain. WIN-35428 has been used in research to better understand the role of dopamine in various neurological and psychiatric conditions, such as Parkinson's disease, schizophrenia, and substance abuse disorders.

Chemistry

WIN-35428 belongs to the phenethylamine and amphetamine families, which are broad categories of chemicals that include both therapeutic drugs and substances of abuse. Its chemical name is 2β-Carbomethoxy-3β-phenyltropane, and it is structurally related to cocaine, differing mainly by the absence of a tropane ring ester linkage. The presence of the carbomethoxy group in the molecule is what gives WIN-35428 its potent dopamine reuptake inhibition properties.

Pharmacology

The primary mechanism of action of WIN-35428 is the inhibition of the dopamine transporter (DAT), which is responsible for the reuptake of dopamine from the synaptic cleft back into the presynaptic neuron. By inhibiting DAT, WIN-35428 increases the concentration of dopamine in the synaptic cleft, enhancing dopaminergic neurotransmission. This action is similar to that of cocaine, although WIN-35428 is reported to have a higher affinity for the DAT and is more selective, making it a valuable tool for research.

Research Applications

WIN-35428 has been extensively used in research to explore the dopamine system. Its ability to selectively inhibit dopamine reuptake has made it a useful compound in studies investigating the role of dopamine in behavior, reward, and neuroplasticity, as well as in models of neurological and psychiatric disorders. Additionally, WIN-35428 has been used to study the pharmacological properties of the DAT and to screen for potential therapeutic agents in the treatment of conditions like depression and substance abuse.

Legal Status

The legal status of WIN-35428 varies by country, but it is often regulated under research chemical laws to prevent its misuse. Given its potent effects and structural similarity to cocaine, WIN-35428 is typically not available for general use and is restricted to research settings.

Safety and Toxicology

As with many research chemicals, the safety profile of WIN-35428 is not well-established. Its use is primarily in controlled laboratory settings, where exposure to humans is limited. Studies in animals have been conducted to assess its pharmacokinetics and potential toxicity, but comprehensive safety data in humans is lacking.