WT1

WT1‏‎ is a gene that encodes a transcription factor involved in the development and function of several organs and tissues in the body. The WT1 gene is located on chromosome 11 and is named after the Wilms' tumor that it is associated with.

Function

The WT1 gene encodes a protein that is a transcription factor, which means it helps control the activity of other genes. This protein plays a crucial role in the development of the kidneys and gonads (testes or ovaries) during embryonic development. It is also involved in the regulation of cell growth and division (proliferation) and the process by which cells mature to carry out specific functions (differentiation).

Clinical significance

Mutations in the WT1 gene can lead to several conditions. The most well-known is Wilms' tumor, a type of kidney cancer that primarily affects children. Other conditions associated with WT1 mutations include Denys-Drash syndrome, Frasier syndrome, and WAGR syndrome, all of which involve kidney abnormalities and other health problems.

Research

Research into the WT1 gene and its associated conditions is ongoing. Scientists are studying the gene's function in normal development and disease, as well as how mutations in the gene lead to the conditions associated with it. This research could lead to new treatments for these conditions in the future.

See also

• Wilms' tumor
• Denys-Drash syndrome
• Frasier syndrome
• WAGR syndrome
• Transcription factor
• Gene