WWOX
WWOX[edit | edit source]
WWOX, also known as WW domain-containing oxidoreductase, is a protein-coding gene that plays a crucial role in various cellular processes. It is located on chromosome 16q23.3 and is highly conserved across different species, indicating its importance in biological functions.
Structure and Function[edit | edit source]
The WWOX gene encodes a protein that contains two WW domains, which are protein interaction modules that bind to proline-rich sequences in other proteins. These domains allow WWOX to interact with a wide range of proteins involved in different signaling pathways.
WWOX has been implicated in several cellular processes, including apoptosis (programmed cell death), DNA repair, and tumor suppression. It acts as a tumor suppressor by regulating the expression of genes involved in cell growth and proliferation. Additionally, WWOX has been shown to modulate the activity of various transcription factors, further highlighting its role in gene regulation.
Clinical Significance[edit | edit source]
Mutations or alterations in the WWOX gene have been associated with various human diseases, including cancer. Loss of WWOX expression or function has been observed in several types of cancer, such as breast, lung, and pancreatic cancer. This suggests that WWOX plays a critical role in preventing the development and progression of tumors.
Furthermore, studies have shown that WWOX expression levels can serve as a prognostic marker in certain cancers. Reduced WWOX expression has been correlated with poor patient outcomes, indicating its potential as a predictive biomarker for disease progression and response to treatment.
Role in Neurological Disorders[edit | edit source]
In addition to its involvement in cancer, WWOX has also been implicated in neurological disorders. Studies have shown that alterations in WWOX expression or function can contribute to the development of neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease. WWOX has been found to regulate the clearance of toxic protein aggregates and protect against neuronal cell death, suggesting its potential as a therapeutic target for these disorders.
References[edit | edit source]
See Also[edit | edit source]
Search WikiMD
Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro / Zepbound) available.
Advertise on WikiMD
|
WikiMD's Wellness Encyclopedia |
| Let Food Be Thy Medicine Medicine Thy Food - Hippocrates |
Translate this page: - East Asian
中文,
日本,
한국어,
South Asian
हिन्दी,
தமிழ்,
తెలుగు,
Urdu,
ಕನ್ನಡ,
Southeast Asian
Indonesian,
Vietnamese,
Thai,
မြန်မာဘာသာ,
বাংলা
European
español,
Deutsch,
français,
Greek,
português do Brasil,
polski,
română,
русский,
Nederlands,
norsk,
svenska,
suomi,
Italian
Middle Eastern & African
عربى,
Turkish,
Persian,
Hebrew,
Afrikaans,
isiZulu,
Kiswahili,
Other
Bulgarian,
Hungarian,
Czech,
Swedish,
മലയാളം,
मराठी,
ਪੰਜਾਬੀ,
ગુજરાતી,
Portuguese,
Ukrainian
Medical Disclaimer: WikiMD is not a substitute for professional medical advice. The information on WikiMD is provided as an information resource only, may be incorrect, outdated or misleading, and is not to be used or relied on for any diagnostic or treatment purposes. Please consult your health care provider before making any healthcare decisions or for guidance about a specific medical condition. WikiMD expressly disclaims responsibility, and shall have no liability, for any damages, loss, injury, or liability whatsoever suffered as a result of your reliance on the information contained in this site. By visiting this site you agree to the foregoing terms and conditions, which may from time to time be changed or supplemented by WikiMD. If you do not agree to the foregoing terms and conditions, you should not enter or use this site. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates Wikipedia, licensed under CC BY SA or similar.
Contributors: Prab R. Tumpati, MD
