Willebrand
Willebrand Disease is a genetic disorder that prevents blood from clotting properly. It is named after the Finnish physician Erik von Willebrand, who first described it in the 1920s. The disease is caused by a deficiency in von Willebrand factor (VWF), a protein that is necessary for platelet adhesion.
Symptoms[edit | edit source]
Symptoms of Willebrand Disease include frequent nosebleeds, bleeding gums, easy bruising, and excessive bleeding after surgery or injury. Women with the disease may experience heavy menstrual periods.
Types[edit | edit source]
There are three types of Willebrand Disease: Type 1, Type 2, and Type 3. Type 1 is the mildest and most common form, while Type 3 is the most severe.
Diagnosis[edit | edit source]
Diagnosis of Willebrand Disease involves blood tests to measure the amount of von Willebrand factor in the blood and its activity level. Genetic testing may also be used.
Treatment[edit | edit source]
Treatment for Willebrand Disease may include medications to increase the level of von Willebrand factor in the blood, replacement therapies, and in some cases, surgical procedures.
See also[edit | edit source]
References[edit | edit source]
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Contributors: Prab R. Tumpati, MD
