Willebrand

Willebrand Disease is a genetic disorder that prevents blood from clotting properly. It is named after the Finnish physician Erik von Willebrand, who first described it in the 1920s. The disease is caused by a deficiency in von Willebrand factor (VWF), a protein that is necessary for platelet adhesion.

Symptoms

Symptoms of Willebrand Disease include frequent nosebleeds, bleeding gums, easy bruising, and excessive bleeding after surgery or injury. Women with the disease may experience heavy menstrual periods.

Types

There are three types of Willebrand Disease: Type 1, Type 2, and Type 3. Type 1 is the mildest and most common form, while Type 3 is the most severe.

Diagnosis

Diagnosis of Willebrand Disease involves blood tests to measure the amount of von Willebrand factor in the blood and its activity level. Genetic testing may also be used.

Treatment

Treatment for Willebrand Disease may include medications to increase the level of von Willebrand factor in the blood, replacement therapies, and in some cases, surgical procedures.

See also

• Hemophilia
• Blood clotting disorders
• Genetic disorders

References

Willebrand Resources
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