Xaliproden

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Xaliproden


Xaliproden is a drug that was under development for the treatment of Amyotrophic lateral sclerosis (ALS) and chemotherapy-induced peripheral neuropathy. It was developed by Sanofi-Aventis, but its development was discontinued in 2006 due to unfavorable results in phase III clinical trials.

History[edit | edit source]

Sanofi-Aventis, a global pharmaceutical company, began the development of Xaliproden in the early 2000s. The drug was intended to treat Amyotrophic lateral sclerosis (ALS), a progressive neurodegenerative disease that affects nerve cells in the brain and spinal cord, and chemotherapy-induced peripheral neuropathy, a common side effect of cancer treatment.

Mechanism of Action[edit | edit source]

Xaliproden is a serotonin 1A receptor agonist. The serotonin 1A receptor is a subtype of the serotonin receptor, which is a group of G protein-coupled receptors and ligand-gated ion channels found in the central and peripheral nervous systems. By acting on this receptor, Xaliproden was believed to have neuroprotective effects.

Clinical Trials[edit | edit source]

Xaliproden underwent phase III clinical trials for the treatment of ALS and chemotherapy-induced peripheral neuropathy. However, the results were not favorable, and Sanofi-Aventis discontinued the development of the drug in 2006.

Discontinuation[edit | edit source]

The discontinuation of Xaliproden's development was a significant setback for Sanofi-Aventis. The company had invested heavily in the drug's development, and the failure of the phase III trials represented a significant financial loss.

See Also[edit | edit source]

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