ZNF821

Ideogram human chromosome 16

ZNF821 is a protein-coding gene located on chromosome 18 in humans. It plays a crucial role in regulating gene expression and is involved in various cellular processes. The ZNF821 gene encodes a zinc finger protein that functions as a transcriptional repressor, controlling the activity of specific genes.

Function

ZNF821 belongs to the Krüppel C2H2-type zinc finger protein family, which is known for its role in DNA binding and transcriptional regulation. This protein interacts with DNA sequences to modulate gene expression by either activating or repressing transcription. ZNF821 has been implicated in the regulation of cell proliferation, differentiation, and development.

Structure

The ZNF821 protein contains multiple zinc finger domains, which are essential for its DNA-binding activity. These domains enable ZNF821 to recognize specific DNA sequences and exert its regulatory functions on target genes. The structural organization of ZNF821 allows it to interact with other proteins and form complexes that influence gene expression.

Role in Disease

Aberrant expression or mutations in the ZNF821 gene have been associated with certain diseases, including cancer. Dysregulation of ZNF821 expression can disrupt normal cellular processes and contribute to the development of various malignancies. Further research is needed to fully understand the implications of ZNF821 in disease pathogenesis.

Interactions

ZNF821 has been shown to interact with several other proteins involved in transcriptional regulation and chromatin remodeling. These interactions modulate the activity of ZNF821 and influence its function in gene expression control. Understanding the protein-protein interactions of ZNF821 is essential for elucidating its role in cellular processes.