Zero-order absorption
Zero-order absorption refers to a pharmacokinetic process where a drug is absorbed at a constant rate, regardless of its concentration. This type of absorption is less common than first-order absorption, where the rate of absorption is directly proportional to the drug concentration. Zero-order absorption is significant in the context of drug delivery systems and pharmacology, as it can affect the drug concentration in the bloodstream, and consequently, the drug's efficacy and safety profile.
Mechanism[edit | edit source]
In zero-order absorption, the drug enters the circulation at a constant rate until the administered dose is completely absorbed. This contrasts with first-order absorption, where the rate decreases as the drug concentration decreases. Zero-order kinetics is often observed in situations where the drug absorption or elimination processes are saturated. This means that the system involved in the drug's absorption or elimination is operating at maximum capacity, and the rate no longer increases with an increase in drug concentration.
Clinical Significance[edit | edit source]
Zero-order absorption is particularly relevant for drugs with a narrow therapeutic index, where maintaining a constant plasma concentration is crucial for therapeutic efficacy and avoiding toxicity. Drugs that follow zero-order kinetics include ethanol, phenytoin, and aspirin at high doses. Understanding the absorption kinetics of these drugs is essential for appropriate dosing regimens to achieve desired therapeutic effects while minimizing adverse effects.
Pharmacokinetic Models[edit | edit source]
Pharmacokinetic models incorporating zero-order absorption are used to predict the concentration of a drug in the body over time. These models are crucial for the development of controlled-release formulations that aim to maintain a constant drug concentration in the bloodstream, enhancing the therapeutic effect and reducing side effects.
Applications[edit | edit source]
Controlled-release formulations that utilize zero-order absorption kinetics are designed to release drugs at a constant rate. These formulations are beneficial for managing chronic conditions, such as diabetes mellitus and hypertension, where maintaining steady drug levels is essential for effective management. Additionally, zero-order release systems can improve patient compliance by reducing the frequency of dose administration.
Challenges[edit | edit source]
Designing drug delivery systems that achieve zero-order absorption can be challenging due to the complex interplay of factors that influence drug absorption and elimination. Factors such as the physicochemical properties of the drug, the design of the delivery system, and the physiological characteristics of the individual can affect the achievement of zero-order kinetics.
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Contributors: Prab R. Tumpati, MD