Zinc finger protein 84

Ideogram human chromosome 12

Zinc finger protein 84

Zinc finger protein 84, also known as ZNF84, is a protein that in humans is encoded by the ZNF84 gene. This gene is located on chromosome 19 and belongs to the C2H2-type zinc finger protein family. Zinc finger proteins are a class of proteins that contain zinc finger domains, which are small protein structural motifs that bind zinc ions.

Structure

Zinc finger protein 84 contains multiple zinc finger domains, which are involved in DNA binding and transcriptional regulation. These domains typically consist of a short alpha helix and two beta strands that coordinate a zinc ion. The specific arrangement of amino acids in the zinc finger domain allows for sequence-specific DNA binding.

Function

Zinc finger protein 84 is thought to play a role in gene regulation by binding to specific DNA sequences and influencing the expression of target genes. It may act as a transcription factor, controlling the activation or repression of gene transcription in response to various cellular signals.

Clinical Significance

Mutations in the ZNF84 gene or dysregulation of zinc finger protein 84 expression have been associated with certain diseases and conditions. Further research is needed to fully understand the implications of these genetic variations on human health.