Zona incerta

Zona Incerta is a region of the brain that is part of the subthalamus. It is located ventral to the thalamus and dorsal to the substantia nigra and Fields of Forel. The name "zona incerta" is Latin for "zone of uncertainty," which reflects the historical lack of knowledge about its function.

File:Zona Incerta.png

Zona Incerta in the human brain

Anatomy

The zona incerta is a horizontally elongated region of gray matter that extends through the dorsal half of the subthalamus. It is bounded medially by the hypothalamus, laterally by the internal capsule, and dorsally by the thalamus. The zona incerta is divided into three main parts: the rostral, intermediate, and caudal zones.

Function

The exact function of the zona incerta is still not fully understood. However, it is known to be involved in several important functions, including pain perception, sleep regulation, and motor control. It is also thought to play a role in attention and consciousness.

Clinical significance

Due to its involvement in pain perception and motor control, the zona incerta has been targeted in deep brain stimulation (DBS) for the treatment of Parkinson's disease, essential tremor, and chronic pain.

See also

• Subthalamus
• Thalamus
• Deep brain stimulation

References

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