Zuclomiphene citrate

Zuclomiphene citrate is a nonsteroidal isomer of clomiphene citrate, a drug commonly used in fertility treatment. It is one of the two isomers found in clomiphene citrate, the other being enclomiphene.

Chemistry

Zuclomiphene citrate is a geometric isomer, meaning it has the same molecular formula as enclomiphene but a different spatial arrangement of atoms. It is a triazine derivative and is classified as a selective estrogen receptor modulator (SERM).

Pharmacology

Zuclomiphene citrate acts as an estrogen antagonist in the hypothalamus, inhibiting the negative feedback of estrogen on gonadotropin-releasing hormone (GnRH) production. This leads to an increase in the release of luteinizing hormone (LH) and follicle-stimulating hormone (FSH), which in turn stimulate the ovaries to produce and release eggs.

Clinical Use

Zuclomiphene citrate is used in the treatment of anovulation, a condition where the ovary does not release an oocyte during a menstrual cycle. It is also used in oligospermia, a male fertility issue characterized by a low sperm count.

Side Effects

Potential side effects of zuclomiphene citrate include hot flashes, ovarian hyperstimulation syndrome, and multiple pregnancies.

See Also

• Clomiphene citrate
• Enclomiphene
• Selective estrogen receptor modulator
• Anovulation
• Oligospermia

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