Enclomifene
Enclomifene[edit | edit source]
Enclomifene is a nonsteroidal selective estrogen receptor modulator (SERM) that is used primarily in the treatment of male hypogonadism and as a fertility agent. It is one of the two geometric isomers of clomifene, the other being zuclomifene.
Mechanism of Action[edit | edit source]
Enclomifene acts by binding to estrogen receptors in the hypothalamus, which leads to an increase in the release of gonadotropin-releasing hormone (GnRH). This, in turn, stimulates the pituitary gland to secrete luteinizing hormone (LH) and follicle-stimulating hormone (FSH), which promote the production of testosterone in the testes.
Clinical Uses[edit | edit source]
Enclomifene is primarily used in the treatment of male hypogonadism, a condition characterized by low levels of testosterone. It is also used as a fertility agent in men, as it can increase sperm production by stimulating the testes.
Male Hypogonadism[edit | edit source]
In cases of male hypogonadism, enclomifene is used to restore normal testosterone levels. This can help alleviate symptoms such as fatigue, decreased libido, and loss of muscle mass.
Fertility Treatment[edit | edit source]
Enclomifene is used to treat male infertility by increasing sperm count and motility. It is often prescribed when low sperm count is a contributing factor to infertility.
Side Effects[edit | edit source]
Common side effects of enclomifene include hot flashes, mood swings, and headaches. In some cases, it may cause visual disturbances or gastrointestinal discomfort.
Pharmacokinetics[edit | edit source]
Enclomifene is administered orally and is well absorbed from the gastrointestinal tract. It undergoes hepatic metabolism and is excreted primarily in the feces.
Related Compounds[edit | edit source]
Enclomifene is closely related to clomifene, which is a mixture of enclomifene and zuclomifene. Clomifene is also used as a fertility agent in women to induce ovulation.
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