Zydis

Orally disintegrating tablet technology

Zydis is a proprietary technology used in the formulation of orally disintegrating tablets (ODTs). This technology is designed to improve the convenience and compliance of medication administration, particularly for patients who have difficulty swallowing traditional tablets or capsules.

Overview

Zydis technology was developed to create tablets that dissolve rapidly in the mouth without the need for water. This is particularly beneficial for patients with dysphagia, the elderly, children, and those with mental health conditions who may be non-compliant with traditional oral dosage forms.

Technology

The Zydis formulation process involves freeze-drying the active pharmaceutical ingredient (API) along with other excipients to create a porous tablet structure. This structure allows the tablet to disintegrate quickly upon contact with saliva. The process includes the following steps:

• Preparation of the formulation: The API is mixed with excipients such as gelatin, mannitol, and other stabilizers.
• Freeze-drying: The mixture is poured into pre-formed blisters and subjected to a freeze-drying process, which removes moisture and creates a porous matrix.
• Packaging: The tablets are sealed in blister packs to protect them from moisture and ensure stability.

Advantages

Zydis ODTs offer several advantages over traditional tablets:

• Rapid disintegration: Tablets dissolve in seconds, providing quick onset of action.
• No need for water: Convenient for patients who have difficulty swallowing or do not have immediate access to water.
• Improved compliance: Easier administration for pediatric and geriatric patients.
• Enhanced stability: The freeze-drying process can improve the stability of certain APIs.

Applications

Zydis technology is used in a variety of therapeutic areas, including:

• Antipsychotics: Medications for mental health conditions such as schizophrenia and bipolar disorder.
• Antiemetics: Drugs used to prevent nausea and vomiting.
• Analgesics: Pain relief medications.

Related pages

• Orally disintegrating tablet
• Dysphagia
• Pharmaceutical formulation