Α,N,O-TMS
Chemical compound
Α,N,O-TMS is a chemical compound that belongs to the class of organosilicon compounds. It is a derivative of trimethylsilyl (TMS) groups, which are commonly used in organic chemistry for the protection of functional groups during synthesis.
Chemical Structure[edit | edit source]
Α,N,O-TMS is characterized by the presence of a trimethylsilyl group attached to an amine (N) and an alcohol (O) functional group. The chemical structure can be represented as a silicon atom bonded to three methyl groups and one additional group that contains both nitrogen and oxygen atoms.
Synthesis[edit | edit source]
The synthesis of Α,N,O-TMS typically involves the reaction of a suitable amine and alcohol with chlorotrimethylsilane (ClSi(CH₃)₃) in the presence of a base such as triethylamine. This reaction results in the substitution of the chlorine atom with the amine and alcohol groups, forming the Α,N,O-TMS compound.
Applications[edit | edit source]
Α,N,O-TMS is primarily used in organic synthesis as a protective group. The trimethylsilyl group is stable under a variety of conditions, making it useful for protecting sensitive functional groups during multi-step synthesis processes. It can be removed under mild conditions, typically using fluoride ions, to regenerate the original functional groups.
Properties[edit | edit source]
Α,N,O-TMS is a volatile and hydrophobic compound. It is typically a colorless liquid at room temperature. The presence of the trimethylsilyl group imparts significant steric bulk, which can influence the reactivity and selectivity of the compound in chemical reactions.
Safety and Handling[edit | edit source]
As with many organosilicon compounds, Α,N,O-TMS should be handled with care. It is important to use appropriate personal protective equipment (PPE) such as gloves and goggles when working with this compound. It should be stored in a cool, dry place away from moisture and incompatible substances.
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