Α5IA

Α5IA‏‎ is a potent and selective inverse agonist for the CB1 receptor, the primary molecular target of the endocannabinoid system within the brain. This compound is used in scientific research and has been studied in the context of various neurological and psychological conditions.

Chemistry

Α5IA‏‎ is a synthetic compound that belongs to the aminoalkylindole family. It is structurally related to other cannabinoid receptor inverse agonists such as Rimonabant and AM251. The chemical structure of Α5IA‏‎ allows it to bind to the CB1 receptor with high affinity and selectivity.

Pharmacology

As an inverse agonist for the CB1 receptor, Α5IA‏‎ exerts its effects by binding to the same receptor sites as endogenous cannabinoids like anandamide and 2-AG, but induces an opposite effect. This means that instead of activating the receptor, Α5IA‏‎ inhibits its activity, reducing the effects of endogenous cannabinoids.

Research and Clinical Implications

Research on Α5IA‏‎ and similar compounds has implications for a variety of neurological and psychological conditions, including obesity, addiction, pain, and neurodegenerative diseases. By modulating the activity of the endocannabinoid system, these compounds could potentially be used to develop new therapeutic strategies.

See Also

• Cannabinoid receptor
• Endocannabinoid system
• Inverse agonist
• Rimonabant
• AM251

References

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