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1-(3-Chlorophenyl)-4-(2-phenylethyl)piperazine (1-3CPP) is a chemical compound that belongs to the class of organic compounds known as piperazines. Piperazines are characterized by their two nitrogen atoms in the six-membered ring, making them part of the larger family of heterocyclic compounds. The specific structure of 1-3CPP includes a piperazine ring substituted at one end by a 3-chlorophenyl group and at the other by a 2-phenylethyl group. This compound is of interest in the field of pharmacology and medicinal chemistry due to its potential biological activity and use as a building block in the synthesis of more complex molecules.

Chemistry[edit | edit source]

1-(3-Chlorophenyl)-4-(2-phenylethyl)piperazine is a synthetic molecule that can be classified as a substituted piperazine. The presence of the chlorophenyl and phenylethyl groups influences the chemical properties and reactivity of the molecule. The synthesis of 1-3CPP involves the reaction of suitable starting materials in the presence of a base, followed by purification steps to isolate the desired product.

Pharmacology[edit | edit source]

The pharmacological profile of 1-3CPP is not well-documented, as it is primarily of interest as a precursor or intermediate in the synthesis of potential therapeutic agents. Compounds in the piperazine class often exhibit a range of biological activities, including acting on the central nervous system (CNS). They can interact with various neurotransmitter receptors, which may lead to potential applications in treating disorders such as depression, anxiety, and schizophrenia. However, the specific activity of 1-3CPP at these receptors, if any, has not been extensively studied.

Potential Applications[edit | edit source]

Research into compounds like 1-3CPP is driven by the search for new drugs with improved efficacy and safety profiles. By modifying the structure of 1-3CPP, chemists can synthesize new compounds with the potential for activity against various diseases. The role of 1-3CPP in drug discovery is primarily as a chemical precursor for the synthesis of more complex molecules that may exhibit desirable pharmacological properties.

Safety and Toxicology[edit | edit source]

The safety, toxicity, and pharmacokinetics of 1-3CPP in humans have not been established. As with many research chemicals, caution should be exercised when handling and experimenting with 1-3CPP. Proper safety protocols, including the use of personal protective equipment (PPE) and working in a well-ventilated area or fume hood, are recommended.


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Contributors: Prab R. Tumpati, MD