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1-(3-Chlorophenyl)-4-(2-phenylethyl)piperazine (1-3-CPP) is a chemical compound that belongs to the class of organic compounds known as piperazines. Piperazines are characterized by their two nitrogen atoms in the six-membered ring, which is part of a larger class of compounds known as heterocyclic compounds. The specific structure of 1-3-CPP includes a piperazine ring substituted with a 3-chlorophenyl group and a 2-phenylethyl group. This compound is of interest in the field of pharmacology and medicinal chemistry due to its potential biological activity and its use as a precursor or intermediate in the synthesis of more complex chemical entities.

Chemistry[edit | edit source]

1-3-CPP is a synthetic organic molecule that contains several functional groups, including a piperazine ring, a chlorophenyl group, and a phenylethyl group. The presence of these groups influences the chemical properties and reactivity of the compound. The chlorophenyl group, in particular, can participate in various chemical reactions due to the presence of the chlorine atom, which is a good leaving group. The phenylethyl group adds to the lipophilicity of the molecule, potentially affecting its pharmacokinetic properties.

Pharmacology[edit | edit source]

The pharmacological profile of 1-3-CPP is not well-documented in the public domain, as it is primarily of interest as a research chemical or as an intermediate in the synthesis of potential therapeutic agents. Compounds containing the piperazine ring are known to interact with a variety of biological targets, including neurotransmitter receptors and transporters. Therefore, 1-3-CPP could potentially exhibit activity at central nervous system targets, although specific activities would depend on further structural modifications and in vitro and in vivo testing.

Potential Uses[edit | edit source]

Given its structural features, 1-3-CPP may serve as a valuable building block in the synthesis of novel compounds with potential therapeutic applications. Its ability to serve as an intermediate in the synthesis of more complex molecules makes it of interest in drug discovery and development efforts, particularly in areas where piperazine-containing compounds have shown therapeutic promise, such as in the treatment of psychiatric disorders, pain management, and infectious diseases.

Safety and Toxicology[edit | edit source]

The safety profile and toxicological properties of 1-3-CPP have not been extensively studied. As with all research chemicals, caution should be exercised in handling and experimentation. Potential risks associated with exposure include toxicity to various organ systems, depending on the dose and route of exposure. Environmental impact and safety measures should be considered in the synthesis and use of this compound.


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Contributors: Prab R. Tumpati, MD