From WikiMD's Food, Medicine & Wellness Encyclopedia

1-(4-Trifluoromethyl-phenyl)-piperazine (TFMPP) is a chemical compound that belongs to the class of piperazine derivatives. It is known for its psychoactive effects and has been used in scientific research as a tool to study the serotonin system.

Chemistry[edit | edit source]

TFMPP is a derivative of piperazine, a class of organic compounds that contain a six-membered ring with two nitrogen atoms at opposite positions in the ring. The chemical structure of TFMPP includes a trifluoromethyl group (-CF3) attached to the phenyl ring, which is connected to the piperazine ring. This structure is responsible for its unique pharmacological properties.

Pharmacology[edit | edit source]

TFMPP acts as a non-selective serotonin receptor agonist, meaning it can activate multiple types of serotonin receptors in the brain. It has been found to have a particular affinity for the 5-HT1A, 5-HT1B, and 5-HT2A receptors. Activation of these receptors can lead to a variety of effects, including changes in mood, perception, and behavior.

Use in Research[edit | edit source]

Due to its effects on the serotonin system, TFMPP has been used in scientific research as a tool to study this system. It can be used to induce a temporary increase in serotonin activity, which can help researchers understand the role of this neurotransmitter in various physiological and psychological processes.

Legal Status[edit | edit source]

The legal status of TFMPP varies by country. In some countries, it is classified as a controlled substance due to its potential for abuse and its psychoactive effects. In others, it is legal to possess and use for research purposes.

Safety[edit | edit source]

As with any psychoactive substance, the use of TFMPP carries potential risks. These can include psychological effects such as anxiety and paranoia, as well as physical effects such as increased heart rate and blood pressure. It is important for users to be aware of these risks and to use the substance responsibly.

See Also[edit | edit source]


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Contributors: Prab R. Tumpati, MD