1-Amino-5-phosphonoindan-1-carboxylic acid

Chemical structure of 1-Amino-5-phosphonoindan-1-carboxylic acid

1-Amino-5-phosphonoindan-1-carboxylic acid (APICA) is a chemical compound that acts as a selective antagonist of the metabotropic glutamate receptor subtype mGluR2 and mGluR3. It is primarily used in scientific research to study the role of these receptors in the central nervous system.

Chemical Structure and Properties

1-Amino-5-phosphonoindan-1-carboxylic acid is an indane derivative, characterized by the presence of an indan ring system with an amino group, a phosphono group, and a carboxylic acid group. The chemical formula of APICA is C₁₀H₁₂NO₅P, and it has a molecular weight of 257.18 g/mol.

The compound is a white to off-white crystalline powder that is soluble in water and other polar solvents. The presence of both the phosphono and carboxylic acid groups makes it a zwitterionic compound, which can affect its solubility and interaction with biological molecules.

Pharmacological Action

APICA functions as an antagonist at the mGluR2 and mGluR3 receptors, which are part of the group II metabotropic glutamate receptors. These receptors are G-protein coupled receptors that modulate neurotransmission in the brain. By blocking these receptors, APICA can inhibit the effects of glutamate, the primary excitatory neurotransmitter in the brain.

The blockade of mGluR2 and mGluR3 by APICA has been shown to affect various neurological processes, including synaptic plasticity, learning, and memory. This makes APICA a valuable tool in neuroscience research for understanding the role of glutamate signaling in these processes.

Applications in Research

APICA is used extensively in preclinical studies to investigate the function of mGluR2 and mGluR3 receptors. It has been employed in studies exploring the pathophysiology of neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease, as well as in research on psychiatric disorders like schizophrenia and depression.

By using APICA to selectively block mGluR2 and mGluR3, researchers can better understand the contribution of these receptors to disease states and evaluate the potential of targeting these receptors for therapeutic intervention.

Safety and Handling

As with many research chemicals, APICA should be handled with care in a laboratory setting. Appropriate safety measures, including the use of personal protective equipment and proper ventilation, should be employed to minimize exposure. The compound should be stored in a cool, dry place, away from light and moisture to maintain its stability.

Related Pages

• Metabotropic glutamate receptor
• Neurotransmitter
• Glutamate (neurotransmitter)
• G-protein coupled receptor